简介：1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐，MPTP hydrochloride是可渗透血脑屏障的 多巴胺 神经毒素，能诱导帕金森综合症。
1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐物理化学性质：
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沸点 |
258.6ºC at 760mmHg |
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分子式 |
C12H16ClN |
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分子量 |
209.715 |
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闪点 |
105.8ºC |
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精确质量 |
209.097122 |
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PSA |
3.24 |
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LogP |
3.1454 |
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蒸汽压 |
0.0136mmHg at 25°C |
1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐详细介绍：
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中文名称： |
1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 |
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中文别名： |
1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐;1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐;MPTP盐酸盐;1-甲基-4-苯基-1,2,3,6-四氢嘧啶盐酸盐;2,4,6-三硝基甲苯;MPTP,1-甲基-4-苯基-1,2,3,6-四氢嘧啶 |
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英文名称： |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride |
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英文别名： |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride;1-Methyl-4-phenyl-1,;Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride;MPTP;1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineHydrochloride;1-methyl-4-phenyl-3,6-dihydro-2H-pyridine,hydrochloride;MPTP Hydrochloride;MPTP hydrochloride;Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride (8CI,9CI);1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinehydrochloride |
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CAS号： |
23007-85-4 |
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分子式： |
C12H16CLN |
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分子量： |
209.72 |
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详细描述 |
博飞美科商城提供的[Sigma-Aldrich]1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Hydrochloride为博飞美科出品的其它生化试剂,产品稳定,定制速度快,极大地方便了广大科研客户的使用需求。产品包装为100MG，安全运输。 属性： 形式：powder 质量水平：200 drug control：kontrollierte Droge in Deutschland 颜色：white to off-white SMILES string：Cl[H].CN1CCC(=CC1)c2ccccc2 InChI：1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H InChI key：KOWJANGMTAZWDT-UHFFFAOYSA-N 包装： 10, 100 mg in serum bottle 生化/生理作用： 多巴胺能神经毒素。 查询关键词:“23007-85-4，1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐，MPTP Hydrochloride，Sigma-Aldrich，上海现货”。 |
1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐参考文献：
[1]. Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question). Life Sci., 1985, 36, No. 3, 201-12.
[2]. Desole M S, et al. Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat. Source:Pharmacol.Biochem.Behav., 1996, 54, No. 2, 377-83.
[3]. Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83.
[4]. Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13(1):180.
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