[Perfemiker]357400-13-6|NNC 55-0396，技术资料

简介：NNC 55-0396是Mibefradil衍生物，是T型钙离子通道阻断剂。

NNC 55-0396物理化学性质：

沸点	713.8ºC at 760mmHg
分子式	C30H40Cl2FN3O2
分子量	564.562
闪点	385.5ºC
精确质量	563.248
PSA	58.22
LogP	7.6385

NNC 55-0396详细介绍：

中文名称：	1-溴-2-(二氟甲基)-4-氟苯
中文别名：	1-溴-2-(二氟甲基)-4-氟苯
英文名称：	NNC 55-0396
英文别名：	Cyclopropanecarboxylicacid,(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylester, hydrochloride (1:2);(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE;Cyclopropanecarboxylicacid,(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-...;Cyclopropanecarboxylicacid,(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-;NNC 55-0396 dihydrochloride;NNC 55-0396 dihydrochloride,(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylcyclopropanecarboxylatedihydrochloride;NNC 55-0396
CAS号：	357400-13-6
分子式：	C30H38FN3O2.2CLH
分子量：	564.56
详细描述：	博飞美科提供357400-13-6，NNC 55-0396，Perfemiker，上海现货。 Medlife，致力于提供高品质、高性价比小分子化合物的产品。 Medlife小分子化合物大量库存，提供超过2万种的抑制剂、激动剂、拮抗剂等产品，是药物及疾病研究的重要原料供应商。 T型钙离子通道阻断剂,NNC 55-0396是Mibefradil衍生物，是T型钙离子通道阻断剂。查询关键词:“357400-13-6，NNC 55-0396，PC11878，Perfemiker，上海现货”。

NNC 55-0396参考文献：

[1]. Arnulfo Quesadaa, Peter H. Bui, Gregg E. Homanics，et al. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology. 2011,659 (1): 30-36.

[2]. Timo Strünker, Normann Goodwin, Christoph Brenker, et al. The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature, 2011,471, 382-386.

[3]. Hideto Miwa, Jinsoo Koh, Yoshinori Kajimoto, et al. Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. Pharmacology Biochemistry and Behavior. 2011,97(4): 656-659.

[4]. Li M, Hansen JB, Huang L, et al. Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396. Cardiovasc Drug Rev. 2005 Summer;23(2):173-96.

[5]. Huang L, Keyser BM, Tagmose TM, et al. NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004 Apr;309(1):193-9.