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发布日期:2023/2/28 15:37:00

简介:NNC 711是GAT-1(GABA转运体1)的有效和选择性抑制剂,对hGAT-1的IC50为40 nM。NNC-711在体内具有抗惊厥和镇痛作用,并表现出认知增强活性。

NNC 711物理化学性质:

沸点

541.2ºC at 760 mmHg

分子式

C21H23ClN2O3

分子量

386.872

闪点

281.1ºC

精确质量

386.14

PSA

62.13

LogP

3.9122

蒸汽压

1.52E-12mmHg at 25°C

 

NNC 711详细介绍:

中文名称:

NNC 711

英文名称:

NNC 711

英文别名:

3-Pyridinecarboxylicacid, 1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-1,2,5,6-tetrahydro-,hydrochloride (1:1);1-[2-(benzhydrylideneamino)oxyethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid,hydrochloride;3-Pyridinecarboxylicacid, 1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-1,2,5,6-tetrahydro-,hydro...;NNC 711;1,2,5,6-Tetrahydro-1-[2-[[(diphenylMethylene)aMino]oxy]ethyl]-3-pyridinecarboxylicacidhydrochloride;Nnc-711;NO 711;NO-711 hydrochloride;Oxyntomodulin;1-[2-[[(Diphenylmethylene)imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride hydrochloride;NNC-711 hydrochloride;NO-711;NNC711,HCl;YZYRTEYMUTWJPL-UHFFFAOYSA-N;NO-711 HCL POTENT GABA UPTAKE IN;1,2,5,6-Tetrahydro-1-(2-(((diphenylmethylene)amino)oxy]ethyl)-3-pyridinecarboxylicacidhydrochloride;1-[2-[[(diphenylmethylene)imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride;1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE

CAS号:

145645-62-1

分子式:

C21H22N2O3.HCL

分子量:

386.87

详细描述:

博飞美科提供145645-62-1,NNC 711,Perfemiker,上海现货。

Medlife,致力于提供高品质、高性价比小分子化合物的产品。

Medlife小分子化合物大量库存,提供超过2万种的抑制剂、激动剂、拮抗剂等产品,是药物及疾病研究的重要原料供应商。

GABA摄取抑制剂,NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.

查询关键词:145645-62-1NNC 711PC12236,Perfemiker,上海现货”。

 

NNC 711参考文献:

[1]. Borden LA, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.

[2]. O'Connell AW, et al. Anti-ischemic and cognition-enhancing properties of NNC-711, a gamma-aminobutyric acid reuptake inhibitor. Eur J Pharmacol. 2001 Jul 13;424(1):37-44.

[3]. Li Y,et al. Analgesic effect of intrathecally γ-aminobutyric acid transporter-1 inhibitor NO-711 administrating on neuropathic pain in rats. Neurosci Lett. 2011 Apr 20;494(1):6-9.

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