| 产品名称： |
辛伐他汀杂质H |
| 中文别名： |
6(R)-[2-(8(S)-羟基]-2(S),6(R)-二甲基-1,2,6,7,8,8a(R)-六氢-1（S）-萘基]乙基-4（R）-羟基-3,4,5,6-四氢-2H-吡喃-2-酮;6(R)-[2-(8(s)-羟基]-2(s),6(r)-二甲基-1,2,6,7,8,8a(r)-六氢-1(s)-萘]乙基-4(r)-羟基-3,4,5,6-四氢-2H-吡喃-2-酮;辛伐他汀内酯二醇;辛伐他汀杂质H;洛伐他汀二醇内酯 |
| 英文名称： |
(4R,6R)-4-Hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one |
| 英文别名： |
(4R,6R)-4-Hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one;6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy;(4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one;6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-h...;6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro...;6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-py;6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-diMethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one;Antibiotic MB 530A;Monacolin J;(4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one |
| 品牌： |
PERFEMIKER |
| CAS号： |
79952-42-4 |
| 分子式： |
C19H28O4 |
| 分子量： |
320.42 |
| 纯度： |
≥99.0% |
| 详细描述： |
辛伐他汀内酯二醇用途 Monacolin J 是胆固醇合成抑制剂，能够抑制 HMG-CoA reductase 的活性。辛伐他汀系列杂质，用于辛伐他汀药物研发中的有关物质研究和检查。提供质量证书COA（含工艺路线、详细结构确证图谱解析、含量标定等）。 辛伐他汀内酯二醇生物活性 描述Monacolin J 是胆固醇合成抑制剂，能够抑制 HMG-CoA reductase 的活性。 相关类别 信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR) 研究领域 >> 代谢疾病 靶点 HMG-CoA reductase[1] 体外研究Monacolin J是胆固醇生物合成的抑制剂，并抑制HMG-CoA还原酶的活性。 Monacolin J的Na盐在1.2μg/ mL时对还原酶产生50％的抑制[1]。 溶解度 体外： 在DMSO中10mM 储备液 1 mM3.1209 mL15.6045 mL31.2090 mL 5 mM0.6242 mL3.1209 mL6.2418 mL 10 mM0.3121 mL1.5605 mL3.1209 mL 存储 请将产品存放在分析证书中的建议条件下。 运输室温;可能会有所不同 SMILESO=C1C[C@H](O)C[C@@H](CC[C@H]2[C@@H](C)C=CC3=C[C@H](C)C[C@H](O)[C@]23[H])O1 参考文献 [1]. Endo A, et al. Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J Antibiot (Tokyo). 1985 Mar;38(3):420-2. 相关活性 小分子瑞舒伐他汀钙 | 氟伐他汀钠 水合物 | 普伐他汀钠 | 美伐他汀 | 尼可沙喷 | 克利贝特 | SR12813 | 3-羟基-3-甲基戊二酸 辛伐他汀内酯二醇物理化学性质 密度1.2±0.1 g/cm3 沸点535.7±50.0 °C at 760 mmHg 分子式C19H28O4 分子量320.423 闪点191.2±23.6 °C 精确质量320.198761 PSA66.76000 LogP1.81 蒸汽压0.0±3.2 mmHg at 25°C 折射率1.558 辛伐他汀内酯二醇英文别名 Antibiotic MB 530A (4R,6R)-4-Hydroxy-6-{2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]ethyl}tetrahydro-2H-pyran-2-one 2H-Pyran-2-one, 6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-, (4R,6R)- Monacolin J (4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one Lovastatin diol lactone Simvastatin EP Impurity H |
沪公网安备31011402010658号 
(%5bC%40%40%5d(%5bH%5d)(%5bC%40%5d(%5bH%5d)(%5bC%40%40%5d(%5bH%5d)(%5bC%40%40%5d1(%5bH%5d)C(%5bH%5d)(%5bH%5d)O%5bC%40%40%5d1(%5bH%5d)%5bC%40%40%5d(%5bH%5d)(%5bC%40%5d(%5bH%5d)(%5bC%40%40%5d(%5bH%5d)(%5bC%40%40%5d(%5bH%5d)(C(%5bH%5d)(%5bH%5d)O%5bH%5d)O1)O%5bH%5d)O%5bH%5d)O%5bH%5d)O%5bH%5d)O%5bH%5d)O%5bH%5d)OC1%3dC(%5bH%5d)C(%5bH%5d)%3dC(%5bH%5d)C2%3dC(%5bH%5d)C3C(%5bH%5d)%3dC(C(%5bH%5d)(%5bH%5d)%5bH%5d)OC(C%3d3C(%3dC12)O%5bH%5d)%3dO)
